NEW
Multi-modal layer modeling reveals in vivo pathology in ALS
Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of the motor system and the loss of motor control. A systematic in-vivo description of the microstructural changes in primary motor cortex (M1) that characterise early-stage ALS, and their subsequent development, is so far lacking. We combined submillimeter structural 7 Tesla (7T) MRI data, functional localisers of body parts and automated layer modelling to create for the first time layer-specific in vivo pathology maps of M1 in living ALS-patients with reference to age-, gender-, handedness- and education-matched controls. The pathology maps reveal a layer-specific profile of ALS pathology in M1, and uncover a potential role of low-myelin borders in the disease progress. A very-slow progressing patient shows a distinct pathology profile compared to the other patients. Our study shows that layer-specific markers of in-vivo pathology can be identified in ALS-patients with a single 7T-MRI measurement after first diagnosis, and that such data provide critical insights into the individual disease state. Read the full article: [link]
Multi-modal layer modeling reveals in vivo pathology in ALS
Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of the motor system and the loss of motor control. A systematic in-vivo description of the microstructural changes in primary motor cortex (M1) that characterise early-stage ALS, and their subsequent development, is so far lacking. We combined submillimeter structural 7 Tesla (7T) MRI data, functional localisers of body parts and automated layer modelling to create for the first time layer-specific in vivo pathology maps of M1 in living ALS-patients with reference to age-, gender-, handedness- and education-matched controls. The pathology maps reveal a layer-specific profile of ALS pathology in M1, and uncover a potential role of low-myelin borders in the disease progress. A very-slow progressing patient shows a distinct pathology profile compared to the other patients. Our study shows that layer-specific markers of in-vivo pathology can be identified in ALS-patients with a single 7T-MRI measurement after first diagnosis, and that such data provide critical insights into the individual disease state. Read the full article: [link]
RESEARCH
Layer-specific vulnerability is a mechanism of topographic map aging
Topographic maps form a critical feature of cortical organization, yet are poorly described with respect to their microstructure in the aging brain. Using parcellation-inspired techniques, we show that the output layer 5 of primary motor cortex (M1) shows a particular vulnerability to age-related increased iron, while layer 5 and the superficial layer show increased diamagnetic substance in older adults, likely reflecting calcifications. We provide a novel 3D model of M1 microstructure, where body parts form distinct structural units, but layers show specific vulnerability toward age-related degeneration. Our findings have implications for understanding basic principles of cortical aging. Read the full article: [link]
Layer-specific vulnerability is a mechanism of topographic map aging
Topographic maps form a critical feature of cortical organization, yet are poorly described with respect to their microstructure in the aging brain. Using parcellation-inspired techniques, we show that the output layer 5 of primary motor cortex (M1) shows a particular vulnerability to age-related increased iron, while layer 5 and the superficial layer show increased diamagnetic substance in older adults, likely reflecting calcifications. We provide a novel 3D model of M1 microstructure, where body parts form distinct structural units, but layers show specific vulnerability toward age-related degeneration. Our findings have implications for understanding basic principles of cortical aging. Read the full article: [link]
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TOOL
Tongue Tracker (TT): A new automated tool to assess bulbar dysfunction in older adults & ALS patients Bulbar symptoms, including difficulty swallowing and speaking, are common in amyotrophic lateral sclerosis (ALS) and other neurological disorders, such as stroke. We developed an open-source tool called Tongue Tracker (TT) to quantify bulbar function by training a neural network to track kinematic tongue features of short video clips of lateral tongue movements. We used TT to detect quantitative markers of bulbar dysfunction in ALS and older adults, and show that the method is sensitive to detect pathology-related alterations in bulbar function. Read the full article: [link] |
RESEARCH
The organizational principles of 'de-differentiated' cortical maps
A common model of cortical aging assumes that more de-differentiated cortical maps link to worse everyday behavior. We show using 7 Tesla MRI that older adults' S1 maps are not more de-differentiated then younger adults' maps when looking at standard markers of cortical de-differentiation. Rather, specific local and global map changes characterize aging topographic maps, where classical features of de-differentation link to better everyday behavior of the hand. We therefore introduce a new feature-based model of topographic map aging. Read the full article: [link]
The organizational principles of 'de-differentiated' cortical maps
A common model of cortical aging assumes that more de-differentiated cortical maps link to worse everyday behavior. We show using 7 Tesla MRI that older adults' S1 maps are not more de-differentiated then younger adults' maps when looking at standard markers of cortical de-differentiation. Rather, specific local and global map changes characterize aging topographic maps, where classical features of de-differentation link to better everyday behavior of the hand. We therefore introduce a new feature-based model of topographic map aging. Read the full article: [link]
OHBM
See here Video presentations by Alicia Northall, Peng Liu and Juliane Döhler on human sensorimotor aging described with 7T-MRI
See here Video presentations by Alicia Northall, Peng Liu and Juliane Döhler on human sensorimotor aging described with 7T-MRI
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METHOD
Topographic layer imaging as a tool to track neurodegenerative disease spread in M1
One important feature that is often left out when diagnosing and analyzing disease spread in primary motor cortex (M1, for example in motor neuron disease) is the inhomogeneous architecture of M1 with respect to cortical layers but also topographic units. We therefore propose that combining 3D layer imaging with topographic mapping serves as ideal tool to understand which microstructural changes in M1 determine disease progression. Read the full article: [link]
Topographic layer imaging as a tool to track neurodegenerative disease spread in M1
One important feature that is often left out when diagnosing and analyzing disease spread in primary motor cortex (M1, for example in motor neuron disease) is the inhomogeneous architecture of M1 with respect to cortical layers but also topographic units. We therefore propose that combining 3D layer imaging with topographic mapping serves as ideal tool to understand which microstructural changes in M1 determine disease progression. Read the full article: [link]
RESEARCH
Impaired remapping of social relationships in older adults
Social relationships are a central aspect of our everyday life and are critical to maintain mental health. Yet, our ability to adapt to changes in social relationships as a consequence of changes in behavioral patterns is an under-investigated topic. In this paper, we combine VR with a social interaction paradigm and show that younger adults alter their behavioral pattern when an avatar changes its behavior (in the domains "power" and "affiliation"), whereas older adults show a reduction in such a "remapping" of social space. Our data provide first evidence that older adults have impaired abilities to "remap" the social space, similar to their impairments in remapping spatial environments during spatial navigation. Read the full article: [link]
Impaired remapping of social relationships in older adults
Social relationships are a central aspect of our everyday life and are critical to maintain mental health. Yet, our ability to adapt to changes in social relationships as a consequence of changes in behavioral patterns is an under-investigated topic. In this paper, we combine VR with a social interaction paradigm and show that younger adults alter their behavioral pattern when an avatar changes its behavior (in the domains "power" and "affiliation"), whereas older adults show a reduction in such a "remapping" of social space. Our data provide first evidence that older adults have impaired abilities to "remap" the social space, similar to their impairments in remapping spatial environments during spatial navigation. Read the full article: [link]
RESEARCH
Preserved body representations in advanced age
The rubber hand illusion is an often used paradigm to investigate multisensory body representations in health and disease, but it has rarely been investigated with respect to age-related changes in older adults. We show that there are no significant differences in explicit and implicit markers of the rubber hand illusion between younger adults (aged 20-30 years) and older adults (aged > 65 years). This indicates preserved pathways for establishing a multisensory representation of the bodily self in advanced age. Read the full article: [link]
Preserved body representations in advanced age
The rubber hand illusion is an often used paradigm to investigate multisensory body representations in health and disease, but it has rarely been investigated with respect to age-related changes in older adults. We show that there are no significant differences in explicit and implicit markers of the rubber hand illusion between younger adults (aged 20-30 years) and older adults (aged > 65 years). This indicates preserved pathways for establishing a multisensory representation of the bodily self in advanced age. Read the full article: [link]
CONCEPT
Changes in embodiment influence cognitive aging
Aging is associated with a number of deficits in sensorimotor and cognitive functions. We outline that a high number of age-related cognitive deficits arise from body-related processing differences. We propose a novel NFL-framework of bodily aging to conceptualize these changes. Key insight: Sensory and cognitive deficits on older age link to age-related changes in embodiment. Read the full articles: [link]
Changes in embodiment influence cognitive aging
Aging is associated with a number of deficits in sensorimotor and cognitive functions. We outline that a high number of age-related cognitive deficits arise from body-related processing differences. We propose a novel NFL-framework of bodily aging to conceptualize these changes. Key insight: Sensory and cognitive deficits on older age link to age-related changes in embodiment. Read the full articles: [link]
FUNDING
SFB-1436: Project B04 "Effects of hippocampal vascularization patterns on the neuronal resources of MTL neurocognitive circuits"
DFG-Einzelprojekt: "Cortical Microstructure & Aging"
EKFS-Grant: "Topography and Plasticity of Cortical Microstructure in ALS characterized with 7T MRI"
SFB-1436: Project B04 "Effects of hippocampal vascularization patterns on the neuronal resources of MTL neurocognitive circuits"
DFG-Einzelprojekt: "Cortical Microstructure & Aging"
EKFS-Grant: "Topography and Plasticity of Cortical Microstructure in ALS characterized with 7T MRI"
